Contemporary Stratification Analysis

Gender Stratification in Contemporary Urban Japan

Contemporary Reviews in Cardiovascular Medicine Contemporary Insights and Strategies for Risk Stratification and Prevention of Sudden Death in Hypertrophic Cardiomyopathy

After 50 years of recognition and study, it is evident that hypertrophic cardiomyopathy (HCM) is a particularly heterogeneous and unpredictable disease with respect to its clinical expression and natural history.1–5 Sudden death (SD) continues to be the most devastating complication of HCM, dating from its modern description.6 However, there were virtually no effective strategies for SD prevent...

Mediation analysis with principal stratification.

In assessing the mechanism of treatment efficacy in randomized clinical trials, investigators often perform mediation analyses by analyzing if the significant intent-to-treat treatment effect on outcome occurs through or around a third intermediate or mediating variable: indirect and direct effects, respectively. Standard mediation analyses assume sequential ignorability, i.e. conditional on co...

Contemporary considerations for risk stratification, sudden death and prevention in hypertrophic cardiomyopathy.

Sudden death has been the most devastating, unpredictable and recognisable complication of hypertrophic cardiomyopathy (HCM), since the modern description of the disease by Teare over 40 years ago. HCM is now recognised as the most common cause of sudden cardiac death in young people, including trained athletes, 3 although only a minority of all HCM patients are susceptible to the risk of sudde...

Some Principles of Stratification: A Critical Analysis